The top portion of the figure is the total ion chromatogram (TIC) of the extract. The term deconvolution is used here in the broad sense of extracting signals from a complex mixture, as depicted in Figure 1.ĭeconvolution is the goal of AMDIS (Automatic Mass Spectral Deconvolution and Identification Software) developed by NIST (National Institute of Standards and Technology) for detecting chemicals in violation of Chemical Weapons Convention.įigure 2 is an example of using AMDIS to identify trace levels of one of the target compounds, methyl parathion, in grape extract. Two powerful GC/MS techniques-Retention Time Locking (RTL) and peak deconvolution-have been combined to create a quantitation and screening tool that can identify 567 pesticides and endocrine disrupters from a single run in a minute or two.Įasily find target compounds in complex matrices This is a time-consuming process it can take an experienced analyst an hour to review/confirm one data file. Background subtraction and manual integration are often required to be certain of the results. It is always very difficult to identify target compounds from a high matrix background because the matrix affects the ion ratios of the target compounds. Typical target compound analysis requires finding target ions and meeting qualifier ion ratios. New software eliminates manual data processingīy Chin-Kai Meng, Ph.D., and Mike Szelewski Agilent Newsletter - Find Hidden Target Compounds
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